Studies on Down's Syndrome and Maternal Age
نویسندگان
چکیده
Details of clinical, genetic and karyotyping investigations carried out on thirty patients with Down's syndrome are described. All the patients showed Trisomy - 21,The information relating to the maternal age revealed that women in the age group of 15-35 also had cases of Down's syndrome which is in contrast to the findings made in western countries.
منابع مشابه
The role of maternal serum alpha-fetoprotein, human chorionic gonadotrophin and oestriol in the antenatal screening of Down's syndrome.
The use of maternal age alone to identify pregnant mothers at risk of a fetus with Down's syndrome has recently been supplemented by maternal serum screening using biochemical markers such as alpha-protein, human chorionic gonadotrophin and oestriol. These tests have been reported to increase the sensitivity of antenatal detection of such fetuses from 35% to 67% with a false positive rate of 5%...
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In this study I investigated the analytical and clinical performance of the measurement of the free beta-subunit of choriogonadotropin (hCG) in normal pregnancies and in pregnancies affected by Down's syndrome. Free beta-hCG in maternal serum has been shown to be increased in Down's syndrome-affected pregnancies and is proportionally increased in more cases than is total hCG. This study confirm...
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The occurrence of Down's syndrome in British Columbia during the period 1972-75 is analyzed with respect to maternal age distribution. This period is compared with previously studied periods. No marked trends are evident in the various age group-specific rates studied. The significance of these findings is discussed in connection with a possible role of environmental nutagens in induction of Do...
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متن کاملRevised estimates of the maternal age specific live birth prevalence of Down's syndrome.
OBJECTIVES To revise the estimates of maternal age specific live birth prevalence of Down's syndrome in the absence of antenatal screening and selective termination using newly available data. SETTING AND DESIGN Data were used from the National Down Syndrome Cytogenetic Register (NDSCR), which contains information on nearly all antenatally or postnatally diagnosed cases of Down's syndrome in ...
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عنوان ژورنال:
دوره 29 شماره
صفحات -
تاریخ انتشار 1987